ABSTRACT
The anti-inflammatory effect of Arnica montana 6cH was evaluated using acute and chronic inflammation models. In the acute, model, carrageenin-induced rat paw oedema, the group treated with Arnica montana 6cH showed 30% inhibition compared to control (P < 0.05). Treatment with Arnica 6cH, 30 min prior to carrageenin, did not produce any inhibition of the inflammatory process. In the chronic model, Nystatin-induced oedema, the group treated 3 days previously with Arnica montana 6cH had reduced inflammation 6 h after the inflammatory agent was applied (P < 0.05). When treatment was given 6 h after Nystatin treatment, there was no significant inhibitory effect. In a model based on histamine-induced increase of vascular permeability, pretreatment with Arnica montana 6cH blocked the action of histamine in increasing vascular permeability.
Subject(s)
Anti-Inflammatory Agents/administration & dosage , Arnica , Edema/drug therapy , Foot Diseases/drug therapy , Inflammation/drug therapy , Phytotherapy , Plant Extracts/administration & dosage , Acute Disease , Analysis of Variance , Animals , Carrageenan , Chronic Disease , Disease Models, Animal , Dose-Response Relationship, Drug , Edema/chemically induced , Foot Diseases/chemically induced , Granulation Tissue/drug effects , Inflammation/chemically induced , Male , Nystatin , Random Allocation , Rats , Rats, Wistar , Time FactorsABSTRACT
Ozonized water increases oxygen local tension. The ozone by itself produces inflammatory reactions in lung epithelium. The action of ozonized water during the inflammatory process was investigated. In rat paw edema induced by carrageenin, the inflammatory process was stimulated by ozonized water (1.2 microg, p.o.) when applied 30 min prior to the induction. In the inflammatory process induced by Freund's Complete Adjuvant, the ozonized water did not interfere in the inflammatory reaction. Furthermore, in gastric ulcers models induced by stress, there was a significant reduction in the incidence of ulcers types I, II and III (P<0.05, Student's t -test).
